Technology Overview
Technology
Our Integrated Comprehensive Droplet Digital Detection, IC3D®, system has been engineered to deliver enrichment-free analytical results as fast and as simply as possible. With unparalleled sensitivity, our system has been designed to process crude samples, eliminating the laborious steps involved in traditional biochemical analysis such as centrifugation, pipetting, and filtration. Fully automated and capable of running a multitude of tests, IC3D® is the most reliable platform for detecting and monitoring pathogenic agents, such as bacteria, viruses, neurological, and cancer biomarkers.
From introducing crude patient samples to getting results in the hands of a qualified healthcare professional, we have eliminated the need for manual work-flow steps that can create contamination risks and produce unreliable results.
Speed
Results in under an hour
Traditionally, suspected samples must be cultivated and enriched before any analysis can be performed. This alone can delay results for days and even weeks. Our proprietary integrated system can deliver test analyses and results with unparalleled speed.
Ease-of-use
Crude unprocessed samples is all you need
Our IC3D® system enables rapid detection of pathogens, biomarkers, and other abnormalities in a variety of unpurified patient sample types, including whole blood, plasma, serum, saliva, sputum, urine, and water. In conventional assays, however, processing and preparing crude samples involves several manual work-flow steps, such as centrifugation, pipetting, and filtration that pose high safety risks, contamination risks, and reliability risks.
Sensitivity
Single cell sensitivity
By systematically blasting the entire blood draw into billions of droplets and screening each one for the presence of target bacteria, we offer unprecedented sensitivity.
Publications
Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection
Dong-Ku Kang, M. Monsur Ali, Kaixiang Zhang, Susan S. Huang, Ellena Peterson, Michelle A. Digman, Enrico Gratton, & Weian Zhao
Nature Communications 5, Article number:5427, doi:10.1038/ncomms6427, 13 November 2014
Digital quantification of miRNA directly in plasma using integrated comprehensive droplet digital detection
Kaixiang Zhang, Dong-Ku Kang, M. Monsur Ali, Linan Liu, Louai Labanieh, Mengrou Lu, Hamidreza Riazifar, Thi N. Nguyen, Jason A. Zell, Michelle A. Digman, Enrico Gratton, Jinghong Li, and Weian Zhao
Lab on a Chip 15, 4217-4226, DOI: 10.1039/C5LC00650C, 14 September 2015